Experience-dependent reactivations of ventral tegmental area neurons in the rat
نویسندگان
چکیده
منابع مشابه
Identification of Rat Ventral Tegmental Area GABAergic Neurons
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons. Although indirect evidence supports the neural circuit postulated by this model, its validity has been called into question by growing evidence for VTA neuronal ...
متن کاملOffline reactivation of experience-dependent neuronal firing patterns in the rat ventral tegmental area.
In a rest period immediately after a task, neurons in the hippocampus, neocortex, and striatum exhibit spatiotemporal correlation patterns resembling those observed during the task. This reactivation has been proposed as a neurophysiological substrate for memory consolidation. We provide new evidence that rodent ventral tegmental area (VTA) neurons are selective for different types of food stim...
متن کاملThe Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition?
Introduction: Antidepressants can modulate brain monoamines by acting on pre-synaptic and postsynaptic receptors. Autoreceptors can reduce the monoamines effect on the somatodendritic or pre-synaptic regions despite its postsynaptic counter effects. The direct effect of some antidepressants is related to its temporal and spatial bioavailability in the vicinity of these receptors (still a matter...
متن کاملElectrophysiological characterization of GABAergic neurons in the ventral tegmental area.
GABAergic neurons in the ventral tegmental area (VTA) play a primary role in local inhibition of mesocorticolimbic dopamine (DA) neurons but are not physiologically or anatomically well characterized. We used in vivo extracellular and intracellular recordings in the rat VTA to identify a homogeneous population of neurons that were distinguished from DA neurons by their rapid-firing, nonbursting...
متن کاملEvaluation of GABA Receptors of Ventral Tegmental Area in Cardiovascular Responses in Rat
Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2011
ISSN: 1471-2202
DOI: 10.1186/1471-2202-12-s1-p107